The copolymer was approved by the fda nearly 50 years ago as a therapeutic reagent to reduce viscosity in the blood before transfusions. Spectrum poloxamer 188, nf is a useful surfactant for the formulation of cosmetics and pharmaceuticals because it increases miscibility. This study evaluated the effects of combined use of two nonionic surfactants, poloxamer 188 and polysorbate 80 into nanovesicles based on 2,3ditetradecyloxypropan1amine cationic lipid destined for gene delivery to central nervous system cells 1. Poloxamer 407 was used to enhance the dissolution rate of several drugs such as atenolol21, piroxicam22 and ibuprofen2324. Poloxamer 188 crs safety data sheet safety data sheet in accordance to regulation ec no. Carefully pipet 25 ml of phthalic anhydridepyridine solution into the flask, touching the tip of the drained pipet to the protrusion in the flask. Poloxamer 188 mechanism of action in ischemic heart. Pdf purified poloxamer 188 for treatment of acute vaso.
Poloxamer is a nonionic block copolymer consisting of hydrophobic polyoxypropylene chains connected to hydrophilic polyoxyethylene chains. Poloxamer 188 emprove expert cell culture optimized cas 9003116 stabilized with 70 ppm bht find msds or sds, a coa, data sheets and more information. If the pdf documents have different page sizes, you can keep the original. Poloxamer 407188 binary thermosensitive hydrogels as. Specialized for use in insect cell culture poloxamer 188 is a surfactant used in cell culture to protect cells in suspension against possible damage during transfer, freezing and thawing, and stirring. Poloxamer 188 altex alternatives to animal experimentation. The effectiveness of the polymer is dependent upon its molecular weight distribution, and a major consideration is the stability of the. In order to control the quality of poloxamer 188 and thus maintain better consistency in manufacturing, multiple small scale screening models were developed. In formulations that include poorly soluble actives, kolliphor p 188 can improve solubility, absorption and. Apr 11, 2014 poloxamer 188 p188 is a nonionic amphiphilic copolymer consisting of a central chain of hydrophobic polyoxypropylene flanked at both ends by hydrophilic polyoxyethylene. View all list of formulations for poloxamer 188 excipient with chemical intermediate, application, finished formulations with poloxamer 188, fine chemicals suppliers and manufacturers details at. It is a polyoxythylenepolyoxypropylene block polymer that is highly effective for use in cattle grazing lush legume pasture or young cereal crops.
Each molecule consists of a central polypropylene oxide chain flanked at either end by a polyethylene oxide segment, thus forming an aba block copolymer structure. Ungraded products supplied by spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for. Poloxamer 188 p188, a multiblock copolymer surfactant, has been. Solid dispersion, ibuprofen, solubility, poloxamer 188 and poloxamer 407. Jan 10, 20 polyvinyl pyrrolidone pvp poloxamer 188 blends were used as appropriate carriers for the preparation of solid dispersions by hot melt extrusion using aripiprazole arip as a poor watersoluble model drug.
Poloxamers 95 table 2 physical and chemical properties of poloxamers. Pdf synthesis and characterization of poloxamer 188grafted. Find patient medical information for poloxamer 188 on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Evacuate the flask carefully at room temperature to a pressure of less than 10 mm of mercury, applying the vacuum slowly to avoid excessive foaming due to entrapped gases. The present invention is directed to a process for producing pharmaceutically acceptable aqueous poloxamer gels in a cost efficient manner. This project was initiated to determine how poloxamer188 p188 improves cardiac function in ischemic heart failure hf. Solid dispersion systems of ziprasidone were prepared with poloxamer 188 in different ratios by melting. Linear aminoterminated poly ethylene glycol methyl ethers mpegnh 2 were purchased from jenkem technology co. Purified poloxamer 188 improves microvascular blood flow by reducing blood viscosity, especially in low shear conditions, and by reducing adhesive frictional forces. P1169, poloxamer 188, nf table of contents product specification safety data sheet sds manufacturer certification of quality management system qms certification of current good manufacturing practices cgmp product bsetse statement product allergen statement product aflatoxin statement. It appears that your browser has javascript disabled. Listing a study does not mean it has been evaluated by the u.
Results of pbt and vpvb assessment no additional information available 12. Poloxamerbased in situ hydrogels for controlled delivery. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Mobility in soil no additional information available 12. The average molecular weight is about 8,500 kd fig. Poloxamer property 124 188 237 338 407 average 20902360 a76809510 68408830 1270017400a 984014600a molecular weight description colorless liquidb white solid asolid solida white solid ph, 2. Prasanthi and others published effect of poloxamer 188 on in vitro dissolution properties of solid dispersions find, read and cite all the research you need on. Pdf poloxamer 188 is a safe biocompatible polymer that can be used in.
From the merging samples found, though, please dont choose one using pdfwriter but instead one using pdfcopy, pdfsmartcopy, pdfcopyfields. Poloxamer 188 is used in the biopharmaceutical industry as a shear protectant where sparging with gases or rapid agitation is required 1. Solid dispersions sds of carvedilol in poloxamer 188 containing different weight. These surfactants are commonly used in industrial applications, cosmetics, and pharmaceuticals. Poloxamers, available also under the trademark pluronics basf, are a class of. Purified poloxamer 188 for treatment of acute vasoocclusive.
Poloxamer 407 pluronic f127 p407 and poloxamer 188 pluronic f68 p188 were purchased from basf china company co. Jan 01, 2002 the stability of poloxamers 188 and 407 at 25 c60% rh and 40 c75% rh was studied for 6 months. Stripped poloxamer place about 500 g of poloxamer 124 into a suitable 3neck, roundbottom flask equipped with a stirrer, a thermometer, a vacuum outlet, and a heating mantle. Aihua liu, brandon wilcock, laixin wang, scott reuschel and. Evaluation of repeat administration of purified poloxamer 188. It has been shown to slowly release drugs merged in the polymer. Nov 17, 2014 melting point nonproprietry name melting point c poloxamer 124 16 poloxamer 188 5257 poloxamer 237 49 poloxamer 338 57 poloxamer 407 5257 28.
Stripped poloxamer place about 500g of poloxamer 124into a suitable 3neck,roundbottom flask equipped with a stirrer,a thermometer,a vacuum outlet,and a heating mantle. Poloxamer 188 p188 is a nonionic amphiphilic copolymer consisting of a central chain of hydrophobic polyoxypropylene flanked at both ends by hydrophilic polyoxyethylene. Pharmacompass api reference price for poloxamer 188 determined using sample data obtained from indian trade importexport. Our regular roundup of notable patents noordin, kneading technique for preparation of binary solid dispersion of meloxicam with poloxamer 188, aaps pharmscitech, 10, 1206 2009. A supercritical fluid extraction process was used to prepare p188p. All spectrum chemical nf products are manufactured, packaged and stored under current good manufacturing practices cgmp per 21cfr part 211 in fda registered and inspected facilities. The process involves premelting the poloxamer prior to mixing with cold water.
Sigmaaldrich offers a number of poloxamer 188 pro products. Use of poloxamer 188 as a membrane sealant on in vitro studies of cardiac myocytes showed signs of possible prevention of cardiomyopathy and heart failure in. Not classified as a dangerous good under transport regulations test specification. The term poloxamer generically applies to the different triblock copolymers made by varying the lengths of the.
Pdfreader has multiple constructors, some take a file name string as argument, some byte arrays containing the pdf. Evacuate the flask carefully at room temperature to a pressure of less than 10mm of mercury,applying the vacuum slowly to avoid excessive foaming due to entrapped gases. For the degraded sample, the formation of formic and acetic acid, and formaldehyde and acetaldehyde was seen with time. Procedure accurately weigh a suitable quantity, not exceeding 15 g, of poloxamer, calculated by multiplying the average molecular weight by 0. It comes in many different forms and grades, including poloxamer 188 surfactant, poloxamer 182, poloxamer 407 nf, 124 grade, 338 nf, and more. It is a nonionic detergent with an average molecular weight of 8400da consisting of a central. Characterization of pharmaceutical polymers by hplc and gpc. Poloxamer 188 p188 is a nonionic amphiphilic copolymer with hemorheologic, antithrombotic, antiinflammatory, and cytoprotective properties. Poloxamer 188 finished formulations with poloxamer 188. Poloxamer 188 p188 is a nonionic block copolymer chemical surfactant known to have cytoprotective, rheologic, antiinflammatory, and antithrombotic activity combined with minimal toxicity. Find patient medical information for poloxamer 188sorbitol solutionurea topical on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Estimated api price per kg in usd for poloxamer 188 obtained from the import, export data from major ports of india. Supelco in a highpressure stainless steel vessel and extracted with carbon dioxide and modifying cosolvents approximately 4 mole % at 6,000 psi and 40 c.
Poloxamer 188 usages, effets secondaires, avis, composition. Poloxamer 188 p188 is a nonionic linear copolymer having an average molecular weight of 8400 daltons and is also referred to as pluronic f68, flocor and rheothrx. A list of us medications equivalent to poloxamer188 is available on the website. Poloxamer 188 solution is used in flow cytometry of chinese hamster ovary cho cells. After cultivation for three days this effect was even more pronounced, ranging from a 1. The new polymer increases robustness of mammalian cells to shear from sparging, resulting in increased viability of cells in the. The aim of the present investigation was to enhance the solubility, dissolution rate of mesalazine with solid dispersion technique using poloxamer 188 and poloxamer 407 as a. Poloxamer 407 was stable in both environments, while 188 was degraded at 40 c75% rh. Differential effects of commercialgrade and purified. In the present investigation solid dispersions with poloxamer 188 were. Surfactant poloxamer 188related decreases in inflammation and tissue damage after experimental brain injury in rats article pdf available in journal of neurosurgery 1011 suppl.
To better understand the properties of poloxamers, a reversedphase liquid chromatography rplc method was developed to characterize the ingredients in poloxamers. While it is accepted that lack of oxygen ischemia results in tissue damage, the direct involvement of membrane injury in the progression of ischemic hf is a relatively novel concept. Poloxamer chemical composition, chemistry information. Poloxamer 188 solution 10%, sterilefiltered, bioreagent. Poloxamer 188 crs 106392125 lc50 fishes 1 mgl lc5096 hour fish 12. The prepared solid dispersions were evaluated for their flow properties. Poloxalene is a nonionic surfactant surface active agent that has been used successfully for the prevention of leguminous bloat for more than 30 years. Kolliphor p 188 is an poloxamer that enables and enhances a wide range of functional applications. It is made up of a main hydrophobic chain of polyoxypropylene bordered on each side by two hydrophilic chains of polyoxyethylene. Variability in poloxamer 188 p188 raw material, which is routinely used in cell culture media to protect cells from hydrodynamic forces, plays an important role in the process performance. Spectrum chemical has exactly the form and grade of poloxamer for your lab needs. It potentially has clinical utility in diverse diseases, such as acute myocardial infarction, acute limb ischemia, shock, acute stroke, heart failure, and sickle cell crisis.
Poloxamers are polymers used for drug delivery as formulation excipients. Poloxamer 188 plays a critical role in protecting cells during cell culture bioprocessing. Poloxamers are amphiphilic nonionic multiblock polymers used in the cosmetic and pharmaceutical industries. Persistence and degradability no additional information available 12.
Description of first aid measures firstaid measures after inhalation. Basf to develop a high purity poloxamer for mast therapeutics. The samples you found and the other commenters pointed you to, use pdfreader to read the source documents. Cell culture performance and impurity levels in poloxamer 188.
Ban similar structures search, synonyms, formulas, resource links, and other chemical information. Corning poloxamer 188, powder acts as surfactant used in cell culture to protect cells in suspension against possible damage during transfer, freezing and thawing, and stirring. Initially, a 5l bioreactor model was established to evaluate cell damage by high sparge rates with different poloxamer 188 lots. Development of small scale cell culture models for. Purified poloxamer 188 pp188 is a nonionic block copolymer surfactant with hemorheologic and antithrombotic properties. Safety assessment of poloxamers 101, 105, 108, 122, 123. To form insitu gel with poloxamer 407 you have to know that this is a thermosensitive polymer. Polyvinyl pyrrolidonepoloxamer188 solid dispersions. Poloxamer 181, surfactant is a nonionic triblock copolymer.
For instant and modified release applications, kolliphor p 188 can act as a stabilizer in oral suspensions. The aim of the present investigation is to enhance the dissolution rate of ziprasidone with solid dispersion technique using poloxamer 188 as a hydrophilic carrier. In this study, a new heparin poloxamer 188 conjugate hp was synthesized and its physicochemical. Moreover, toxicity correlated with the sonolytic degradation of the polymers. Poloxamer 188, surfactant 9003116 p1161 spectrum chemical. Bioaccumulative potential no additional information available 12. The problem with poloxamers poloxamer 188 has become an essential component of cell culture media, but lottolot variability has been a problem for many biopharma manufacturers. Poloxamer 188 protects neurons against ischemiareperfusion. Poloxamer 407 in conjuction with hpmc has been used for rectal delivery of quinine in children koffi et al. Thermogelling properties of purified poloxamer 407.
Acts as surfactant used in cell culture to protect cells in suspension against possible damage during transfer, freezing and thawing, and stirring. Poloxamer, chemical structure, molecular formula, reference. It was suggested that hydrophobic sections of poloxamer 188. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Mechanism investigation for poloxamer 188 raw material. Nov 30, 2012 evaluation of purified poloxamer 188 in vasoocclusive crisis of sickle cell disease epic epic the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Poloxamer 188 emprove expert cell culture optimized cas. Fluorescein isothiocyanate fitc was purchased from sigma st. Poloxamer 188 p188 as a membrane resealing reagent in. Even though tremendous efforts have been spent to understand the mechanism of poloxamers protection, the root cause for lot. Basf corporation was supported on a polystyrene divinyl benzene solid matrix xad4.
Poloxamer 188 supplemented culture medium increases the. Two of the most commonly used poloxamers are poloxamer 188 a80, b27 with molecular weight ranging from 7680 to 9510 da, and poloxamer 407. Poloxamer 188 is a triblock copoloymer of polyethylene oxide and polypropylene oxide with an average of 80 central units of polypropylene oxide, and an average of 27 flanking units of polyethylene oxide. Poloxamer definition of poloxamer by medical dictionary. Characterization of poloxamers by reversedphase liquid. Pdf effect of poloxamer 188 on in vitro dissolution. The physical state of arip in solid dispersions and its dissolution characteristics were tested for different drug contents and various pvpto poloxamer ratios. Purified poloxamer 188 for treatment of acute vasoocclusive crisis of sickle cell disease. Poloxamer 188 is a safe biocompatible polymer that can be used in protein drug delivery system. Wo2009055312a1 process for producing a poloxamer gel. Poloxamer 188 9003116 na na poloxamer 188, added before or immediately after an electrical pulse used for electroporation, decreases the number of dead cells and at the same time does not reduce the number of reversible electropores through which small molecules cisplatin, bleomycin, or propidium iodide can passdiffuse.
Effects of transplanted heparinpoloxamer hydrogel combining dental pulp stem. P188 derives its wide range of therapeutic applications via adherence to hydrophobic surfaces exposed after cell damage, restoring normal hydrated surfaces. Poloxamer 188, surfactant is a nonionic triblock copolymer. Poloxamer 188 is a nonionic detergent that is added to batch mammalian cell cultures to reduce foaming and improve the resistance of cell membranes to hydrodynamic shearing. The addition of poloxamer 188 to liquid media increases mammalian cell yield in agitated cultures, possibly due to association of poloxamer 188 with the cell membrane 2. Combine multiple pdf files into one single pdf document. Sep 14, 2017 in animal models of dmd, carmesealmd poloxamer 188 nf has been shown to improve the efficiency of damaged hearts and the performance of damaged diaphragms with onceaday subcutaneous.
Phrixus pharmaceuticals announces phase 2 clinical trial of. A wide variety of poloxamer 188 options are available to you, such as medicine grade, food grade. Evaluation of repeat administration of purified poloxamer 188 epice the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. What is poloxamer 188 it is a nonionic surfactant, biocompatible copolymer what is it for.